The game runs fine as long as I don't allow my screensaver to ever kick in. It can't recover from any kind of interruption. If I exit the game cleanly, and try to run the game again I get the "Blue Screen of Death"tm and the machine reboots.
I have a Win2k desktop machine as well. AMD Athlon 1.2G with 512MB RAM and an ATI Radeon 64MB video card. I haven't loaded it on this box yet... but I'll report the results when I do.